A 59-year-old client is brought into the emergency room with complaints of chest pain. The client states that the pain is crushing, constrictive pressure that is not relieved with position change. He states that the pain started 3 hours ago in the middle of his chest and radiates down his left arm. The client has a history of diabetes, asthma, and hypertension. Temperature: 99 Blood Pressure: 138/72 Heart Rate: 106 Respiration: 19 ECG: ST segmented depression Troponin: Negative The client is given medication for his unstable angina. Soon after, the client states that he is having difficulty breathing with audible wheezing heard on auscultation. Which of the following is most likely responsible for the symptoms experience by this client?