ABO incompatibility occurs exclusively in Rh-negative mothers with Rh-positive infants, leading to mild anemia but not jaundice, and is easily prevented with Rh immunoglobulin.

ABO incompatibility occurs when the mother's antibodies cross the placenta and attack fetal red blood cells, potentially causing mild hemolytic disease, jaundice. and anemia in the newborn, and it is more common than Rh incompatibility.

ABO incompatibility only occurs if the mother has received multiple blood transfusions during pregnancy, causing maternal antibodies to attack fetal red blood cells, and it rarely affects newborns.

ABO incompatibility occurs when the mother and infant have the same blood type, leading to severe hemolysis, kernicterus, and often requires immediate exchange transfusion.