Only take acetaminophen with this medication if there is breakthrough pain: This medication already contains 325 mg of acetaminophen per tablet in combination with hydrocodone. Taking additional acetaminophen increases the risk of exceeding the maximum recommended daily dose, which can result in hepatotoxicity.

Ensure adequate fluid and fiber intake while taking this medication: Opioids decrease gastrointestinal motility by binding to mu receptors in the enteric nervous system, leading to reduced peristalsis and increased water absorption in the colon. This commonly results in constipation. Increasing fluid and fiber intake helps counteract decreased bowel motility and reduce the risk of opioid-induced constipation.

Do not attempt any complex tasks until you know how you will feel on this drug: Hydrocodone causes central nervous system depression, which may lead to drowsiness, impaired judgment, and slowed reaction time. Clients should avoid driving, operating machinery, or performing tasks requiring alertness until they understand how the medication affects them.

Avoid the concurrent use of any other medications that can cause drowsiness: Combining opioids with other central nervous system depressants such as benzodiazepines, antihistamines, alcohol, or sedative-hypnotics increases the risk of profound sedation and respiratory depression. The additive depressant effects can impair airway protection and ventilation.