The Tylenol may cause liver damage and the aspirin will not. I don't recommend substituting it.

Tylenol is a different category of medication to relieve pain so it may not be as effective as aspirin.

Either aspirin or Tylenol will enhance the pain relief of the celecoxib. It would be acceptable if you are more comfortable with it.

The healthcare provider has prescribed aspirin to prevent cardiac complications that may occur with celecoxib. It would not be a good idea to substitute.