When two or more medications that are hepatotoxic are combined, the risk for liver damage is increased.

Damage to the liver cells can impair the metabolism of many medications, causing medication accumulation in the body and producing adverse effects.

When two or more medications that are hepatotoxic are combined, the risk for liver damage is decreased.

Manifestations of hepatotoxicity include nausea, vomiting, jaundice, dark urine, abdominal discomfort, and anorexia.