Nursing management during administration of opioid analgesics such as Morphine sulfate requires careful monitoring for both therapeutic effects and potentially serious adverse effects. Morphine acts on central opioid receptors to relieve pain but also depresses the central nervous system and gastrointestinal motility. Common complications include respiratory depression, constipation, urinary retention, and hypotension. Preventive care and continuous assessment are essential to ensure patient safety in the postoperative period. Rationale: A. Encouraging physical activity and offering increased fluids helps counteract opioid-induced decreased gastrointestinal motility. Morphine slows peristalsis by binding to mu receptors in the gut, leading to constipation. Early ambulation stimulates bowel function, while adequate hydration softens stool and promotes transit. B. Monitoring the patient's blood pressure closely for hypertension is not appropriate because morphine more commonly causes hypotension rather than elevated blood pressure. It induces vasodilation through histamine release and decreased sympathetic tone, which can lead to orthostatic hypotension. Nursing assessment should therefore focus on detecting low blood pressure and signs of hypoperfusion rather than hypertension. C. Requesting an order for Methylnaltrexone (Relistor) is appropriate for preventing or treating opioid-induced constipation. This medication is a peripherally acting mu-opioid receptor antagonist that reverses the constipating effects of opioids without affecting analgesia. It is useful when conventional laxatives are insufficient, especially in postoperative or chronically treated patients. D. Palpating the patient's lower abdomen every 4 to 6 hours helps assess for urinary retention, a known side effect of opioids. Morphine can reduce bladder tone and inhibit the micturition reflex, leading to retention and bladder distention. Regular assessment allows early detection of complications such as bladder overdistension, which may require catheterization. E. Counting respirations before and after giving the medication is critical due to the risk of respiratory depression. Morphine suppresses the respiratory center in the medulla, decreasing both respiratory rate and depth. Baseline and ongoing monitoring ensures early identification of hypoventilation, allowing timely intervention such as withholding doses or administering an opioid antagonist if necessary.