A. Cyclosporine does not typically cause blindness. While some medications can cause ocular toxicity, cyclosporine’s side effects are primarily related to organ systems like the kidneys and the immune system. Rarely, patients may experience mild visual disturbances, such as blurred vision, but these are uncommon and not considered major adverse effects. Including blindness as a potential adverse effect could cause unnecessary alarm and is not supported by clinical evidence. B. Cyclosporine is a potent immunosuppressant commonly prescribed for organ transplant recipients, autoimmune disorders, or other conditions requiring immune modulation. By suppressing T-cell function and overall immune response, cyclosporine increases susceptibility to opportunistic infections, including fungal infections (like Candida or Aspergillus), viral infections (like cytomegalovirus), and bacterial infections that a healthy immune system would normally control. Nurses must monitor patients closely for early signs of infection, educate them about hygiene and infection prevention, and coordinate with providers for prophylactic measures when indicated. C. Respiratory arrest is not a recognized or direct adverse effect of cyclosporine. While severe infections resulting from immunosuppression could theoretically compromise respiratory function, respiratory arrest is not a common, predictable, or expected outcome from cyclosporine administration. Including this option may reflect confusion with other high-risk medications such as sedatives or opioids. D. Cyclosporine is well-known for its nephrotoxic potential. It can cause vasoconstriction of renal blood vessels, leading to reduced glomerular filtration, electrolyte imbalances, and progressive renal dysfunction. Monitoring kidney function is critical, including frequent assessments of serum creatinine, blood urea nitrogen (BUN), urine output, and in some cases, drug levels (trough levels) to avoid toxicity. Early recognition of nephrotoxicity allows dose adjustment or discontinuation to prevent permanent renal damage. E. Cyclosporine is not commonly associated with causing heart failure. Hypertension is a more frequent cardiovascular concern due to vasoconstriction, which can indirectly strain the heart, but direct cardiotoxicity resulting in heart failure is rare. Therefore, heart failure is not considered a major adverse effect.