Pathophysiology Proctored Exam Jefferson College
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Pathophysiology Proctored Exam Jefferson College
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Question: 1 of 59PATHOPHYSIOLOGY PROCTORED EXAM JEFFERSON COLLEGE
A skin biopsy is examined by light microscopy in the Pathology Department. Neutrophils (polys) are seen attached to endothelial cells lining small blood vessels (shown). What is the most likely reason for this pathologic finding?
Explanation
A. Acute inflammation: Neutrophils are the first responders in acute inflammation. They migrate to sites of injury or infection, adhere to endothelial cells via adhesion molecules (selectins, integrins), and then transmigrate into tissues. The image showing neutrophils attached to vessel walls directly reflects this process. B. Granulomatous inflammation: Characterized by macrophages, epithelioid cells, and giant cells, not neutrophils. C. Chronic inflammation: Involves lymphocytes, plasma cells, and macrophages, with fewer neutrophils. D. Immune complex disease: Can involve neutrophils, but the defining feature is deposition of immune complexes in tissues, often with complement activation and vasculitis. The image specifically highlights neutrophil adhesion, which is more consistent with acute inflammation. E. Hypersensitivity type I: Mediated by IgE and mast cells, leading to eosinophil involvement, not neutrophil adhesion.
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