A client presents to the emergency department with a puncture wound sustained 48 hours ago. Assessment findings include: increasing localized pain, erythema extending beyond the wound margins, temperature 38.6 C (101.5 F), WBC 16,200/mm with 10 percent bands, and blood pressure trending down from baseline. The nurse is analyzing whether the client's condition represents a localized inflammatory response or progression to a systemic inflammatory state. Which pathophysiologic processes should the nurse identify as contributing to the client's current condition? (Select all that apply).